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    Not to be confused with Müllerian.
    The Müllerian Agenesis flag.

    Müllerian Agenesis, Müllerian Aplasia, or Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is an intersex variation that effects 1 in 4,500 AFAB/CTF individuals, in which one is born without a uterus or have a uterus that is not fully developed. They may or may not have lone ovaries, no ovaries, and/or an underdeveloped or incomplete vagina, and may also have hyperandrogenism, due to a lack of estrogen production that may partner this variation.[1]

    One with this variation may or may not have oddly placed kidneys, a single kidney or undersized kidneys, spine abnormalities, hearing issues, or heart defects however this is not always the case, and only tends to be the case when ones variation is more severe.[2] Some of the symptoms may classify one with this variation as physically disabled.

    Individuals with this variation are unable to reproduce as they do have a fully developed uterus, although a uterus transplant may be a possible solution for individuals who would like to get pregnant. Most with this variation are unaware of it until they hit puberty, due to the fact that most do not menstruate.

    In some cases, they may have WNT4 Deficiency, however this is usually not the case.

    Causes

    The cause of this syndrome is unknown. Changes in several genes that are involved in development before birth have been identified in individuals with this syndrome, however, each of these cases has been found in only a few affected individuals, and it is unclear whether these changes cause the syndrome itself. Researchers are working to determine how genetic changes might lead to problems with reproductive system development.[3]

    Flag

    The Müllerian Agenesis flag was coined by Reign of the breadsticcs on May 7th of 2021. It has no confirmed meaning.[4]

    References

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