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[[File:Dawal4s-5472a646-bf4c-4050-973d-768f36f00831.png|thumb|220x220px|The XYY pride flag.
[[File:XYY.png|thumb|218x218px|An alternate XYY pride flag.]]
'''XYY syndrome''', also called '''47,XYY''' or '''Jacob's syndrome''', is an [[CTM]] [[intersex]] variation affecting approximately 1 in 1000
Symptoms of this variation may include delayed development of language and/or motor skills, involuntary tremors or tics, and increased likelihood of seizures, asthma, and learning disabilities. Physical features caused by this variation can include increased height, a large head, flat feet, and widely spaced eyes. Since this variation does not always cause obvious or unusual symptoms, some may go most or all of their lives without knowing they are affected.<ref>https://ghr.nlm.nih.gov/condition/47xyy-syndrome</ref><ref>https://rarediseases.org/rare-diseases/xyy-syndrome/</ref>
These symptoms may classify one with this variation as [[neurodivergent]] or physically [[disabled]].
== History ==
The first published report of a [[Male|man]] with a 47,XYY karyotype was by internist and cytogeneticist Avery Sandberg and colleagues at Roswell Park Memorial Institute in Buffalo, New York in 1961. It was an incidental finding in a normal 44-year-old, 6 ft. [183 cm] tall man of average intelligence who was karyotyped because he had a daughter with Down syndrome. Only a dozen isolated 47,XYY cases were reported in the medical literature in the four years following the first report by Sandberg.<ref>https://en.wikipedia.org/wiki/XYY_syndrome#History</ref>
In December 1965 and March 1966, ''Nature'' and ''The Lancet'' published the first preliminary reports by British cytogeneticist Patricia Jacobs and colleagues at the MRC Human Genetics Unit at Western General Hospital in Edinburgh of a chromosome survey of 315
In January 1968 and March 1968, ''The Lancet'' and ''Science'' published the first U.S. reports of tall, institutionalized XYY
In April 1968, ''The New York Times''—using Telfer as a main source—introduced the XYY genetic variation to the general public in a three-part series on consecutive days that began with a Sunday front-page story about the planned use of the variation as a mitigating factor in two murder trials in Paris and Melbourne—and falsely reported that Richard Speck was an XYY
In December 1968, the ''Journal of Medical Genetics'' published the first XYY review article—by Michael Court Brown, director of the MRC Human Genetics Unit—which reported no overrepresentation of XYY
In May 1969, at the annual meeting of the American Psychiatric Association, Telfer and her Elwyn Institute colleagues reported that case studies of the institutionalized XYY and XXY
In June 1969, the National Institute of Mental Health (NIMH) Center for Studies of Crime and Delinquency held a two-day XYY conference in Chevy Chase, Maryland. In December 1969, with a grant from the NIMH Center for Studies of Crime and Delinquency, cytogeneticist Digamber Borgaonkar at Johns Hopkins Hospital began a chromosome survey of (predominantly African-American)
In the late 1960s and early 1970s, screening of consecutive newborns for sex chromosome abnormalities was undertaken at seven centers worldwide: in Denver (Jan 1964–1974), Edinburgh (Apr 1967–Jun 1979), New Haven (Oct 1967–Sep 1968), Toronto (Oct 1967–Sep 1971), Aarhus (Oct 1969–Jan 1974, Oct 1980–Jan 1989), Winnipeg (Feb 1970–Sep 1973), and Boston (Apr 1970–Nov 1974). The Boston study, led by Harvard Medical School child psychiatrist Stanley Walzer at Children's Hospital, was unique among the seven newborn screening studies in that it only screened newborn
== Flag ==
The XYY Syndrome flag was coined by Deviantart user Pride-Flags on or before January 22nd of 2017. It has no confirmed meaning.<ref>https://www.deviantart.com/pride-flags/art/XYY-Syndrome-658903420</ref>
The second flag was coined by [[User:Cryptocrew|Cryptocrew]], specifically Adora, on May 4th of 2021. It uses some of the same colors of the original flag, but with added meaning. Dark blue represents being assigned male, light blue represents masculine traits, white represents diversity and community, purple represents being close to
== Resources ==
<references />
[[Category:Intersex Traits]]
[[Category:Needs Resource Verification]]
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