:''{{Distinguish|XXYY Syndrome|XXXYY Syndrome|XYYYY Syndrome|XYYY Syndrome}}''
'''49, XXYYY syndrome''' is aan [[intersex]] variation in which a [[CTM]] individual has two extra Y chromosomes and one extra X chromosome. It is a very rare variation amongst [[AMAB|DMAB]] individuals, and it has no estimated rarity.
Those with this variation tend to have facial dysmorphism, mild microcephaly, limitation of supination at the elbows, delayed bone age, and moderate [[Neurodivergent|intellectual disability]].<ref>https://pubmed.ncbi.nlm.nih.gov/8330452/</ref> This variation is often considered a subset of [[Klinefelter Syndrome|kilnefelterKlinefelter syndrome]]. If these symptoms cause any physical struggles, they may be classified as physically [[disabled]].
== Studies ==
Medical professionals looked into tissues sampled for chromosome studies of external [[Ambiguous Genitalia|ambiguous genitalia]] and abdominal gonads, consisting of a left [[Ovotesticular|ovotestis]] and a right primitive testis, and found that they contained cells 46,XX, 47,[[XYY Syndrome|47,XXY]] and 49,XXYYY sex chromosomes.<ref>https://pubmed.ncbi.nlm.nih.gov/13959068/</ref> This implies that those with ambiguous genitalia and/or [[Ovotesticular|ovotestes]] may - in some cases - hold the genetic materiel to bare, grow, or develop a child with XXYYY Syndromesyndrome (if they can ovulate and/or produce sperm.).
== Resources ==
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