''Not to be confused with [[{{Distinguish|XXYY Syndrome]], [[|XXXYY Syndrome]],|XYYYY [[XYYYYSyndrome|XYYY Syndrome]].''}}
'''49,XXYYY syndrome''' is aan [[intersex]] variation in which a [[CTM]] individual has two extra Y chromosomes and one extra X chromosome. It is a very rare variation amongst [[AMAB|DMAB]] individuals, and it has no estimated rarity. ▼
Those with this variation tend to have facial dysmorphism, mild microcephaly, limitation of supination at the elbows, delayed bone age, and moderate [[Neurodivergent|intellectual disability (such as autism]]. )<ref> [https://pubmed.ncbi.nlm.nih.gov/8330452/ ]</ref> This variation is often considered a subset or a related variation toof [[Klinefelter Syndrome| kilnefelterKlinefelter syndrome ]]. If these symptoms cause any physical struggles, they may be classified as physically [[disabled]]. ▼
▲'''49,XXYYY syndrome''' is a [[intersex]] variation in which a [[CTM]] individual has two extra Y chromosomes and one extra X chromosome. It is a very rare variation amongst [[AMAB|DMAB]] individuals, and it has no estimated rarity.
▲Those with this variation tend to have facial dysmorphism, mild microcephaly, limitation of supination at the elbows, delayed bone age, and moderate intellectual disability (such as autism.)<ref>[https://pubmed.ncbi.nlm.nih.gov/8330452/]</ref> This variation is often considered a subset or a related variation to [[Klinefelter Syndrome|kilnefelter syndrome]].
It is important to note that not all the symptoms listed in this page are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation.
== Studies ==
Medical professionals looked into tissues sampled for chromosome studies of external [[Ambiguous Genitalia|ambiguous genitalia]] and abdominal gonads, consisting of a left [[Ovotesticular|ovotestis]] and a right primitive testis, and found that they contained cells 46,XX, 47,[[XYY Syndrome|47,XXY]] and 49,XXYYY sex chromosomes.<ref>[https://www.karger.com/Article/PDF/129719][https://pubmed.ncbi.nlm.nih.gov/13959068/][https://op.europa.eu/en/publication-detail/-/publication/b7a528a6-2d20-4384-9e52-38579a0f3677]</ref> This implies that those with ambiguous genitalliagenitalia and/or [[Ovotesticular|ovotestes]] may - in some cases - hold the genetic materiel to bare, grow, or develop a child with XXYYY Syndromesyndrome (if they can ovulate and/or produce sperm.).
== History ==
This variation appears to have been discovered in 1967 or earlier,
== Resources ==
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1754.1967.tb01693.x
[[Category:Intersex Traits]]
[[Category:TerminologyFlagless Sexes]]
[[Category:Verified Resources]]
[[Category:Pages With No History Section]]
[[Category:Sex Category]]
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