(Created page with "'''49,XXXXY syndrome,''' also sometimes known as '''Fraccaro Syndrome''', is an extremely rare intersex trait in AMAB individuals in which they have three extra X chro...") |
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[[File:49,XXXXY Syndrome flag.png|thumb|The 49,XXXXY Syndrome flag]] |
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'''49,XXXXY syndrome,''' also sometimes known as '''Fraccaro Syndrome''', is an extremely rare [[intersex]] trait in [[AMAB]] individuals in which they have three extra X chromosomes. It occurs in approximately 1 out of 85,000 - 100,000 AMAB individuals. Symptoms of 49,XXXXY syndrome can vary, but usually include learning difficulties/intellectual disabilities, low muscle tone, [[AMAB Hypogonadism|hypogonadism]], infertility, delayed growth, distinctive facial features, and a variety of birth defects that may affect the heart, bones, brain and/or kidneys. |
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'''49,XXXXY Syndrome''', also sometimes known as '''Fraccaro Syndrome''', is an extremely rare [[intersex]] variation in [[AMAB]] or [[CTM]] individuals in which they have three extra X chromosomes.<ref>[[wikipedia:XXXXY syndrome]]</ref> It occurs in approximately 1 out of 85,000 - 100,000 AMAB individuals.<ref>{{Archive|URL=2022.02.11-112931/https://medlineplus.gov/genetics/condition/49xxxxy-syndrome/%23frequency}}</ref> It is considered a variation of [[Klinefelter Syndrome]]. |
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Traits of 49,XXXXY syndrome can vary; however, it usually includes [[User blog:Contie/Neurodivergent|learning difficulties/intellectual disabilities]], [[Secondary Sex Agenesis|low muscle tone]], [[hypogonadism]], delayed growth, dental issues, curved pinky fingers, a variety of congenital disabilities that may affect the heart, bones, brain and/or kidneys, and distinctive facial features such as widely spaced eyes, a flat nose bridge, and epicanthic folds. Some of these symptoms may classify one with this syndrome as physically disabled. |
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It was first diagnosed in 1960, and was named Fraccaro syndrome after the researcher. |
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One common symptom is an undergrown penis ([[Agenital#Micropenis|micropenis]]) and/or undescended testicles ([[Agenital#Cryptorchidism|cryptorchidism]]). This often causes them not to produce as much testosterone, leading them not to grow much body hair and not have many masculine traits. As a result, breast growth may occur. This may also cause an overproduction of estrogen, which may cause them to also fall under [[Aromatase Excess Syndrome]] and/or [[AMAB Hypogonadism]]. All of those with this variation are incapable of sperm production and thus are infertile.<ref>{{Archive|URL=2022.02.11-113135/https://medlineplus.gov/genetics/condition/49xxxxy-syndrome/}}</ref> |
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== Resources == |
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* https://en.wikipedia.org/wiki/49,XXXXY |
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This sex was first diagnosed in 1960 and was named Fraccaro syndrome after the individual who researched it.<ref>{{Archive|URL=2022.02.11-113428/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426158/}}</ref> |
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* https://medlineplus.gov/genetics/condition/49xxxxy-syndrome/ |
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* https://rarediseases.info.nih.gov/diseases/5679/49-xxxxy-syndrome |
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==Flag == |
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FANDOM user ViralSystem created the flag on March 15th, 2021. The greens are for facial features, yellow is for the intersex spectrum, light orange is for chromosomal abnormality, and the rest of the oranges are for community.<ref>{{Archive|URL=2022.02.11-113936/https://lgbta.fandom.com/wiki/XXXXY_Syndrome?commentId=4400000000000108740}}</ref> |
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==References== |
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<references /> |
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[[Category:Intersex Traits]] |
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[[Category:Verified Resources]] |
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[[Category:Sex Category]] |
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Latest revision as of 21:03, 15 June 2024
49,XXXXY Syndrome, also sometimes known as Fraccaro Syndrome, is an extremely rare intersex variation in AMAB or CTM individuals in which they have three extra X chromosomes.[1] It occurs in approximately 1 out of 85,000 - 100,000 AMAB individuals.[2] It is considered a variation of Klinefelter Syndrome.
Traits of 49,XXXXY syndrome can vary; however, it usually includes learning difficulties/intellectual disabilities, low muscle tone, hypogonadism, delayed growth, dental issues, curved pinky fingers, a variety of congenital disabilities that may affect the heart, bones, brain and/or kidneys, and distinctive facial features such as widely spaced eyes, a flat nose bridge, and epicanthic folds. Some of these symptoms may classify one with this syndrome as physically disabled.
One common symptom is an undergrown penis (micropenis) and/or undescended testicles (cryptorchidism). This often causes them not to produce as much testosterone, leading them not to grow much body hair and not have many masculine traits. As a result, breast growth may occur. This may also cause an overproduction of estrogen, which may cause them to also fall under Aromatase Excess Syndrome and/or AMAB Hypogonadism. All of those with this variation are incapable of sperm production and thus are infertile.[3]
History
This sex was first diagnosed in 1960 and was named Fraccaro syndrome after the individual who researched it.[4]
Flag
FANDOM user ViralSystem created the flag on March 15th, 2021. The greens are for facial features, yellow is for the intersex spectrum, light orange is for chromosomal abnormality, and the rest of the oranges are for community.[5]
References
- ↑ wikipedia:XXXXY syndrome
- ↑ https://archive.today/2022.02.11-112931/https://medlineplus.gov/genetics/condition/49xxxxy-syndrome/%23frequency
- ↑ https://archive.today/2022.02.11-113135/https://medlineplus.gov/genetics/condition/49xxxxy-syndrome/
- ↑ https://archive.today/2022.02.11-113428/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426158/
- ↑ https://archive.today/2022.02.11-113936/https://lgbta.fandom.com/wiki/XXXXY_Syndrome?commentId=4400000000000108740