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[[File:Mdp flag.jpg|thumb|200x200px|The MDP Syndrome flag.]] |
[[File:Mdp flag.jpg|thumb|200x200px|The MDP Syndrome flag.]] |
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'''MDP Syndrome (Mandibular hypoplasia-deafness-progeroid syndrome)''' is an [[intersex]] |
'''MDP Syndrome (Mandibular hypoplasia-deafness-progeroid syndrome)''' is an [[intersex]] variation that effects both [[CTF]] and [[CTM]] individuals alike. |
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For CTM individuals, symptoms include [[Agenital|absent or undescended testicles]], [[AMAB Hypogonadism|AMAB hypogonadism]], and possibly [[Aromatase Excess Syndrome|aromatase excess syndrome]] due to the lack of testosterone. This may cause [[Secondary Sex Agenesis|low muscle tone]], low hair growth, and possibly [[feminine]] traits within these individuals |
For CTM individuals, symptoms include [[Agenital|absent or undescended testicles]], [[AMAB Hypogonadism|AMAB hypogonadism]], and possibly [[Aromatase Excess Syndrome|aromatase excess syndrome]] due to the lack of testosterone. This may cause [[Secondary Sex Agenesis|low muscle tone]], low hair growth, and possibly [[feminine]] traits within these individuals |
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In both CTF and CTM individuals, common symptoms include deafness or low hearing, low fat, tight skin, a small lower jaw, insulin resistance, diabetes, an enlarged liver, flexed joints, dental crowding, and possibly a beaked nose. |
In both CTF and CTM individuals, common symptoms include deafness or low hearing, low fat, tight skin, a small lower jaw, insulin resistance, diabetes, an enlarged liver, flexed joints, dental crowding, and possibly a beaked nose. |
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It is important to note that not all the symptoms listed in this page are guaranteed to occur in someone with this |
It is important to note that not all the symptoms listed in this page are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation. |
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== Causes == |
== Causes == |
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This variation is caused by a single codon deletion the ''POLD1'' gene, a gene that codes proteins and is present in all cells. This change can cause development in every cell to be different or impaired, causing the many symptoms listed above. |
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== History == |
== History == |
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