'''Leydig Cell Hypoplasia''' or '''LCH''' is an extremely rare [[intersex]] traitvariation<ref>https://medlineplus.gov/genetics/condition/leydig-cell-hypoplasia/#frequency</ref> that effects [[AMAB]]/[[CTM]] individuals in which the Leydig Cell (a cell that secretes androgens) is underdeveloped. This underdevelopment causes a decrease in androgens and may cause ones male traits to be more [[feminine]] in nature<ref>https://en.wikipedia.org/wiki/Leydig_cell_hypoplasia</ref> One with this condition tends to have [[Ambiguous Genitalia|ambiguous genitals]] or otherwise fall on the [[agenital]] spectrum, [[hypospadias]], decreased body hair, and decreased muscle tone.
The cells underdevelopment causes a decrease in androgens and may cause ones male traits to be more [[feminine]] in nature.
== History ==
There is no confirmation of its original discovery, however it has been known since 1995.
One with this variation tends to have [[Ambiguous Genitalia|ambiguous genitals]], [[agenital|micropenis]], a penis with [[hypospadias]] and/or a bifid scrotum, decreased body hair, and [[Secondary Sex Agenesis|decreased muscle tone]]. In more extreme cases, they may have a vagina, with their testicles being small (microorchidism) and undescended (cryptorchidism).
== Resources ==
*Often [[AMAB Hypogonadism|AMAB hypogonadism]] is seen in these individuals as well, which may cause them to also fall under [[Aromatase Excess Syndrome|aromatase excess syndrome]].<ref>https://medlineplus.gov/genetics/condition/leydig-cell-hypoplasia/#frequency</ref><ref>https://www.cell.com/ajhg/pdf/S0002-9297(07)62597-X.pdf</ref>
== References ==
* https://en.wikipedia.org/wiki/Leydig_cell_hypoplasia
<references />
* https://www.cell.com/ajhg/pdf/S0002-9297(07)62597-X.pdf
[[Category:Intersex Traits]]
[[Category:TerminologyFlagless Sexes]]
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