Gonadal dysgenesis is an intersex bodily/corporeal variation of the atypical embryonic development of the gonads, with reproductive tissue replaced with dysfunctional, fibrous tissue, which is called streak gonads. Streak gonads are a form of aplasia, resulting in hormonal failure that manifests as sexual infantism and infertility, with no initiation of puberty and secondary sex characteristics.[1]
One with this variation cannot ovulate as their reproductive tissue is not formed and is instead replaced with simple tissue. This is usually seen with people who have 45,X/46,XY Mosaicism or Turners syndrome, however it can be a variation amongst itself.
This variation may also cause one to fall under the secondary sex agenesis spectrum.
Swyer Syndrome
Swyer Syndrome is a form of Gonadal Dysgenesis. It is typically affecting an AFAB otherwise or CTF individual with müllerian genitals and a müllerian reproductive system, that have their functionless gonads that are replaced with streak gonads. If left without HRT, they will not experience puberty.[2] This often causes one to also have AFAB Hypogonadism.
The name was chosen to be named after the endocrinologist who first discovered it, Gerald Swyer.[3]
History
Swyer syndrome was first described by G. I. M. Swyer in 1955 in a report of two cases.[3]
Flags
A general Gonadal Dysgenesis flag was coined by Reign of the breadsticcs on May 7th of 2021. It has no confirmed meaning.[4]
A flag for XX Gonadal Dysgenesis was made on July 31st, 2024 by tumblr user dhddmods. The shades of pink represent the "female-like" anatomy of those who have this variation, with the crossed-out circles represent streak ovaries. The "XX" symbols in the center of the flag represent XX chromosomes.
Another flag for XY Gonadal Dysgenesis/Swyer Syndrome was posted on the same date by the same user, dhddmods. In order the color meanings are blueish-purple for "male-associated" chromosomes, pink for "female-like" anatomy, and purple for potential clitoromegaly. The crossed out circles represent streak ovaries while the "XY" symbols in the center of the flag represent XY chromosomes.[5]
- Gallery
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The general Gonadal Dysgenesis flag by Reign of the breadsticcs -
XX Gonadal Dysgenesis flag by tumblr user dhddmods -
Swyer Syndrome/XY Gonadal Dysgenesis flag by by tumblr user dhddmods
Resources
- ↑ wikipedia:Gonadal dysgenesis
- ↑ wikipedia:Gonadal dysgenesis#46,XY Gonadal Dysgenesis
- ↑ 3.0 3.1 wikipedia:Gonadal dysgenesis#History
- ↑ https://lgbta.wikia.org/f/p/4400000000000137332/r/4400000000000449105
- ↑ https://web.archive.org/web/20240813004105/https://www.tumblr.com/dhddmods/757546864357834752/some-intersex-flags-part-3