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[[File:Day6cym-006edcb7-f1a8-4572-9335-0dcbec25304e.png|thumb|220x220px|The estrogen resistance pride flag.]]
'''Estrogen Resistance''' or '''Estrogen Insensitivity Syndrome''' ('''EIS''') is an extremely rare [[Intersex|intersex]] variation only known to affect six individuals so far. Individuals with estrogen resistance have defective estrogen receptors (ER) that cannot achieve their goal. This variation effects both [[CTM]] and [[CTF]] individuals alike.<ref>{{Archive|Site=web|URL=https://www.susans.org/wiki/Estrogen_insensitivity_syndrome}}</ref><ref>{{Archive|Site=web|URL=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413105/}}</ref>
One reported [[AMAB]] individual with EIS was abnormally tall, as estrogens were unable to act close to the epiphyseal line, and put them at risk for osteoporosis and sterile, which suggests that in biological humans, estrogens are necessary for reproduction. One with this variation cannot impregnate anyone, as they are infertile.
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== Flag ==
The flag was coined by Mod Hermy through Pride-color-schemes Tumblr account on June 15th of 2017. It is made to represent an orchid, as orchids are often used as a symbol for intersex individuals.<ref>{{Archive|Site=web|URL=https://pride-color-schemes.tumblr.com/post/161844489245/estrogen-insensitivity-syndrome}}</ref>
== History ==
The first case of this variation was in 1994, in which a CTM individual was discovered to have biological development delays. Upon medical examination, the variation was discovered, making him the first ever case to be reported.<ref>{{Archive|Site=web|URL=https://en.wikipedia.org/wiki/Estrogen_insensitivity_syndrome#History}}</ref>
== EIS siblings ==
Within one of the cases of this variation, two sisters and one brother were all born with EIS. It was concluded upon study that the reason behind this was from high plasma within the 17''β''-estradiol gene. This was due to a defect in forming within the womb, because of the incestual relationship of their parents, who were first cousins.<ref>{{Archive|Site=web|URL=https://en.wikipedia.org/wiki/Estrogen_insensitivity_syndrome#Familial_case}}</ref>
This does ''not'' mean that incestual relations is the ''reason'' for this variation, but rather means that it can intensify the likelihood of it in development.
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