Denys-Drash Syndrome (DDS) is an intersex trait that effects both AFAB and AMAB individuals. It has only around 150-200 reports, however it may be more frequent than this, just without notice. This condition is caused when one WT1 gene- a gene designed for connecting regions of DNA together- fails to properly function. Because of this, proteins that effect genitals and kidneys are effected during development in the womb.
Those with this condition have diffuse glomerulosclerosis, which is a condition that effects ones kidneys abilities to filter waste. Because of this, they have a 90% chance at gaining Wilms tumor, a rare kidney cancer.
AMAB individuals with this condition may have a penis, however they often have ambiguous genitals, undescended testicles (cryptorchidism), or a vagina. Because of this, they typically are infertile and unable to bare children.
AFAB individuals with this condition have a vagina, and the only noticeable trait of DDS is their kidneys. Because of this, they are often diagnosed with other kidney-related conditions, rather than with DDS.