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'''Denys-Drash Syndrome (DDS)''' is an [[intersex]] variation that effects both [[CTF]] and [[CTM]] individuals. It has only around 150-200 reports, however it may be more frequent than this, just without notice (especially for CTF individuals.)<ref>{{Archive|Site=web|URL=https://medlineplus.gov/genetics/condition/denys-drash-syndrome/#frequency}}</ref>
Those with this variation have ''diffuse glomerulosclerosis'', which is a
CTM individuals with this variation may have a penis, however they often have [[Ambiguous Genitalia|ambiguous genitals]], [[Agenital|undescended testicles (cryptorchidism)]], or a vagina. Because of this, they typically are infertile and unable to bare children. They also typically have [[Gonadal Dysgenesis|gonadal dysgenesis]] and/or [[AMAB Hypogonadism|AMAB hypogonadism]] as well.
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''Not to be confused with [[Fraser Syndrome]].''
'''Frasier Syndrome''' is an intersex variation that falls under DDS. It has the same cause (improper function of the ''WT1'' gene) however it is less severe. The symptoms are the same as DDS, just less intense.<ref>{{Archive|Site=web|URL=https://medlineplus.gov/genetics/condition/frasier-syndrome/}}</ref> It is seemingly rare, with only 50 reported cases, however CTF individuals with this variation may be overlooked.<ref>{{Archive|Site=web|URL=https://medlineplus.gov/genetics/condition/frasier-syndrome/#frequency}}</ref>
== Causes ==
This variation is caused when one ''WT1'' gene- a gene designed for connecting regions of DNA together- fails to properly function. Because of this, proteins that effect genitals and kidneys are effected during development in the womb.<ref>{{Archive|Site=web|URL=https://medlineplus.gov/genetics/condition/denys-drash-syndrome/#causes}}</ref>
== History ==
P. Denys and Allan L. Drash first described the syndrome in 1967.<ref>{{Archive|Site=web|URL=https://en.wikipedia.org/wiki/Denys%E2%80%93Drash_syndrome#History}}</ref>
== Resources ==
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