'''Denys-Drash Syndrome (DDS)''' is an [[intersex]] traitvariation that effects both [[AFAB Hypogonadism|AFABCTF]] and [[AMABCTM]] individuals. It has only around 150-200 reports, however it may be more frequent than this, just without notice. This condition is caused when one ''WT1'' gene- a gene designed(especially for connectingCTF regions of DNA together- fails to properly functionindividuals. Because of this, proteins that effect genitals and kidneys are effected during development in the womb)<ref>{{Archive|Site=web|URL=https://medlineplus.gov/genetics/condition/denys-drash-syndrome/#frequency}}</ref>
Those with this conditionvariation have ''diffuse glomerulosclerosis'', which is a condition that effects ones kidneys abilities to filter waste. Because of this, they have a 90% chance at gaining ''Wilms tumor'', a rare kidney cancer.<ref>{{Archive|Site=web|URL=https://medlineplus.gov/genetics/condition/denys-drash-syndrome/}}</ref>
AMABCTM individuals with this conditionvariation may have a penis, however they often have [[Ambiguous Genitalia|ambiguous genitals]], [[Agenital|undescended testicles (cryptorchidism)]], or a vagina. Because of this, they typically are infertile and unable to bare children. They also typically have [[Gonadal Dysgenesis|gonadal dysgenesis]] and/or [[AMAB Hypogonadism|AMAB hypogonadism]] as well.
AFABCTF individuals with this conditionvariation have a vagina, andwhile the only noticeable trait of DDS is their kidneys. Because of this, they are often diagnosed with other kidney-related conditionsvariations, rather than with DDS.
== ResourcesFrasier Syndrome ==
''Not to be confused with [[Fraser Syndrome]].''
'''Frasier Syndrome''' is an intersex variation that falls under DDS. It has the same cause (improper function of the ''WT1'' gene) however it is less severe. The symptoms are the same as DDS, just less intense.<ref>{{Archive|Site=web|URL=https://medlineplus.gov/genetics/condition/frasier-syndrome/}}</ref> It is seemingly rare, with only 50 reported cases, however CTF individuals with this variation may be overlooked.<ref>{{Archive|Site=web|URL=https://medlineplus.gov/genetics/condition/frasier-syndrome/#frequency}}</ref>
* https://medlineplus.gov/genetics/condition/denys-drash-syndrome/#causes
* https://en.wikipedia.org/wiki/Denys%E2%80%93Drash_syndrome
== Causes ==
This variation is caused when one ''WT1'' gene- a gene designed for connecting regions of DNA together- fails to properly function. Because of this, proteins that effect genitals and kidneys are effected during development in the womb.<ref>{{Archive|Site=web|URL=https://medlineplus.gov/genetics/condition/denys-drash-syndrome/#causes}}</ref>
== History ==
P. Denys and Allan L. Drash first described the syndrome in 1967.<ref>{{Archive|Site=web|URL=https://en.wikipedia.org/wiki/Denys%E2%80%93Drash_syndrome#History}}</ref>
== Resources ==
<references />
[[Category:Intersex Traits]]
[[Category:Flagless IdentitiesSexes]]
[[Category:TerminologyVerified Resources]]
[[Category:Sex Category]]
|