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'''De La Chapelle Syndrome''' (also known as '''XX Male Syndrome''' or '''46, XX Testicular Disorder''') is an [[intersex]] variation that effects one in every 20,000 [[AMAB]] or [[CTM]] births in which an individual has [[müllerian]] chromosomes (XX chromosomes) however they have a [[wolffian]] appearance outwardly.<ref>https://en.wikipedia.org/wiki/XX_male_syndrome</ref><ref>https://medlineplus.gov/genetics/condition/46xx-testicular-disorder-of-sex-development/</ref> |
'''De La Chapelle Syndrome''' (also known as '''XX Male Syndrome''' or '''46, XX Testicular Disorder''') is an [[intersex]] variation that effects one in every 20,000 [[AMAB]] or [[CTM]] births in which an individual has [[müllerian]] chromosomes (XX chromosomes) however they have a [[wolffian]] appearance outwardly.<ref>{{Archive|Site=web|URL=https://en.wikipedia.org/wiki/XX_male_syndrome}}</ref><ref>{{Archive|Site=web|URL=https://medlineplus.gov/genetics/condition/46xx-testicular-disorder-of-sex-development/}}</ref> |
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Most with this variation [[Agenital|have small testicles or a missing testicle]] or a urethra opening that is on a unusual spot of the genitals ([[hypospadias]].) On rare occasion, one with this variation may have [[Ambiguous Genitalia|ambiguous genitals]]. Because of this, they may have [[AMAB Hypogonadism]]. |
Most with this variation [[Agenital|have small testicles or a missing testicle]] or a urethra opening that is on a unusual spot of the genitals ([[hypospadias]].) On rare occasion, one with this variation may have [[Ambiguous Genitalia|ambiguous genitals]]. Because of this, they may have [[AMAB Hypogonadism]]. |
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Many with this variation tend to be shorter than average and infertile, however with testosterone treatments ([[Hormone Replacement Therapy|HRT]]) one may have a higher chance at a more natural flow of growth during puberty.<ref>https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/xx-male-syndrome</ref> |
Many with this variation tend to be shorter than average and infertile, however with testosterone treatments ([[Hormone Replacement Therapy|HRT]]) one may have a higher chance at a more natural flow of growth during puberty.<ref>{{Archive|Site=web|URL=https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/xx-male-syndrome}}</ref> |
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A similar intersex variation is [[SERKAL Syndrome]]. |
A similar intersex variation is [[SERKAL Syndrome]]. |
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