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Cryptocrew (talk | contribs) (Expanded on the different forms of this variation.) |
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'''Androgen Resistance''' or '''Androgen Insensitivity Syndrome '''is a rare [[intersex]] trait affecting 1/20,000 to 1/64,000 [[AMAB]] or otherwise [[CTM]] individuals, causing one to be more resistant to androgens (such as testosterone.)<ref>{{Archive|Site=web|URL=hhttp://www.hormones.gr/227/article/androgen-insensitivity-syndrome:-clinical-features-and%E2%80%A6.html}}</ref><ref>{{Archive|Site=web|URL=hhttps://www.sciencedirect.com/science/article/abs/pii/S1521690X0600087X?via%3Dihub}}</ref><ref>{{Archive|Site=web|URL=hhttps://en.wikipedia.org/wiki/Androgen_insensitivity_syndrome}}</ref> |
'''Androgen Resistance''' or '''Androgen Insensitivity Syndrome '''is a rare [[intersex]] trait affecting 1/20,000 to 1/64,000 [[AMAB]] or otherwise [[CTM]] individuals, causing one to be more resistant to androgens (such as testosterone.)<ref>{{Archive|Site=web|URL=hhttp://www.hormones.gr/227/article/androgen-insensitivity-syndrome:-clinical-features-and%E2%80%A6.html}}</ref><ref>{{Archive|Site=web|URL=hhttps://www.sciencedirect.com/science/article/abs/pii/S1521690X0600087X?via%3Dihub}}</ref><ref>{{Archive|Site=web|URL=hhttps://en.wikipedia.org/wiki/Androgen_insensitivity_syndrome}}</ref> |
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This can be a partial ('''Partial Androgen Insensitivity Syndrome'''/'''PAIS'''),<ref>{{Archive|Site=web|URL=hhttps://en.wikipedia.org/wiki/Partial_androgen_insensitivity_syndrome}}</ref> mild ('''Mild Androgen Insensitivity Syndrome'''/'''MAIS'''),<ref>{{Archive|Site=web|URL=hhttps://en.wikipedia.org/wiki/Mild_androgen_insensitivity_syndrome}}</ref> or complete resistance ('''CAIS'''),<ref>{{Archive|Site=web|URL=hhttps://en.wikipedia.org/wiki/Complete_androgen_insensitivity_syndrome}}</ref> and generally causes reduction in [[masculine]] biological traits. |
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⚫ | This can happen because of defects in the testicles or [[AMAB Hypogonadism|hypogonadism]]. This also can sometimes effect those with [[Ambiguous Genitalia|ambiguous genitalia]], as they may produce little to no testosterone. |
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== Complete Androgen Insensitivity Syndrome == |
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'''Complete Androgen Insensitivity Syndrome (CAIS)''' is a subset of this variation, in which one with XY chromosomes has a complete inability for the cells to respond to androgen receptors. Those with CAIS look outwardly [[Müllerian|mullerian]], with a vagina and breasts. They may have [[Agenital|underdeveloped labia and/or clitoral hypoplasia.]] They have testicles that are either within the labia or within the inguinal ring.<ref>https://web.archive.org/web/20221225070702/https://en.wikipedia.org/wiki/Complete_androgen_insensitivity_syndrome#Signs_and_symptoms</ref> |
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Most do not have a uterus, cervix, or fallopian tubes, however in rare cases it does occur. |
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== Partial Androgen Insensitivity Syndrome == |
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'''Partial Androgen Insensitivity Syndrome (PAIS)''' is a subset of this variation, in which one with XY chromosomes has a partial inability of the cell to respond to androgen receptors. Those with PAIS have a penis (possibly with [[hypospadias]], chordee, and/or a bifid scrotum), micropenis, [[clitoromegaly]], or ambiguous genitalia. Those with PAIS have testicles, with cryptorchidism being common. Some also experience mild breast growth. <ref>https://web.archive.org/web/20220916064816/https://en.wikipedia.org/wiki/Partial_androgen_insensitivity_syndrome</ref> |
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== Mild Androgen Insensitivity Syndrome == |
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'''Mild Androgen Insensitivity Syndrome (MAIS)''' is a subset of this variation, in which one with XY chromosomes has a mild inability for the cells to respond to androgen receptors. Those with MAIS appear mostly [[wolffian]], with a penis (sometimes with hypospadias) or micropenis. Some also experience mild breast growth. Those with this variation are infertile and [[Secondary Sex Agenesis|will not develop many secondary sex traits]], however this is typically reversable through testosterone supplements ([[HRT]].)<ref>https://web.archive.org/web/20220916064820/https://en.wikipedia.org/wiki/Mild_androgen_insensitivity_syndrome#Signs_and_symptoms</ref> |
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== Flag == |
== Flag == |