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[[File:Davpdjz-b7bb45df-a6c5-4a87-ace5-caa4ada3db71.png|thumb|220x220px|The 45,X/46,XY mosaicism pride flag.]] |
[[File:Davpdjz-b7bb45df-a6c5-4a87-ace5-caa4ada3db71.png|thumb|220x220px|The 45,X/46,XY mosaicism pride flag.]] |
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'''45,X/46,XY Mosaicism '''or '''Mixed Gonadal Dysgenesis '''is a rare [[intersex]] variation affecting 1 in 15,000 individuals. It is a chromosomal karotype where some of one's cells have an X chromosome and some have XY chromosomes.<ref name=":0"> |
'''45,X/46,XY Mosaicism '''or '''Mixed Gonadal Dysgenesis '''is a rare [[intersex]] variation affecting 1 in 15,000 individuals. It is a chromosomal karotype where some of one's cells have an X chromosome and some have XY chromosomes.<ref name=":0">{{Archive|URL=2022.02.11-103018/https://pride-color-schemes.tumblr.com/post/161844110960/45x46xy-mosaicism}}</ref> Each case is different depending on the exact location and amount of X cells and XY cells in one's body. |
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Those with this variation who are [[CTM]] are typically shorter than usual, with a [[AMAB Hypogonadism|low output of testosterone]], and typically have a [[Agenital|micropenis]] (though they may have a common penis as well.)<ref> |
Those with this variation who are [[CTM]] are typically shorter than usual, with a [[AMAB Hypogonadism|low output of testosterone]], and typically have a [[Agenital|micropenis]] (though they may have a common penis as well.)<ref>{{Archive|URL=2022.02.11-103224/https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=1772}}</ref> |
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For those with this variation who are [[CTF]] are typically born with vaginal aplasia, an [[Clitoromegaly|enlarged clitoris]], and may have only a single vaginal hole that connects both urinal output and sexual output. |
For those with this variation who are [[CTF]] are typically born with vaginal aplasia, an [[Clitoromegaly|enlarged clitoris]], and may have only a single vaginal hole that connects both urinal output and sexual output. |
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Both CTM and CTF individuals with this variation tend to have [[Ambiguous Genitalia|ambiguous genitals]] as well. |
Both CTM and CTF individuals with this variation tend to have [[Ambiguous Genitalia|ambiguous genitals]] as well. |
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One with this variation can have any internal sex organs, though asymmetrical gonads and other structures are common.<ref> |
One with this variation can have any internal sex organs, though asymmetrical gonads and other structures are common.<ref>{{Archive|URL=2022.02.11-103457/https://www.cincinnatichildrens.org/health/m/mixed-gonadal-dysgenesis}}</ref> Depending on how the gonads develop, the output of estrogen and testosterone may vary, however it is common that those with this variation tend to have a [[masculine]] puberty, making CTF individuals with this variation possibly also have [[hyperandrogenism]]. |
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== History == |
== History == |
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The earliest mention of Mixed Gonadal Dysgenesis appears to have been in 1992, with Richard E. Behrman in the 14th edition of the Nelson textbook of Pediatrics.<ref>http:// |
The earliest mention of Mixed Gonadal Dysgenesis appears to have been in 1992, with Richard E. Behrman in the 14th edition of the Nelson textbook of Pediatrics.<ref>{{Archive|URL=2012.05.30-123442/http://www-personal.umd.umich.edu/~jcthomas/JCTHOMAS/1997%20Case%20Studies/N.Justus.html}}</ref> |
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== Flag == |
== Flag == |