[[File:Davpdjz-b7bb45df-a6c5-4a87-ace5-caa4ada3db71.png|thumb|220x220px|The 45,X/46,XY mosaicism pride flag.]]
'''45,X/46,XY Mosaicism ''' or '''Mixed Gonadal Dysgenesis ''' is a rare [[intersex]] variation affecting 1 in 15,000 peopleindividuals. It is a chromosomal conditionkaryotype where some of one's cells have an X chromosome, and some have XY chromosomes.<ref name=":0">{{Archive|URL=2022.02.11-103018/https://pride-color-schemes.tumblr.com/post/161844110960/45x46xy-mosaicism}}</ref> Each case is differentdiffers depending on the exact location and amount of X cells and XY cells in one's body.
For thoseThose with this variation who are [[CTM]], they are typically shorter than usual, with a [[AMAB Hypogonadism|low output of testosterone]], and typically have a [[Agenital|micropenis]] (though they may have a common penis as well.).<ref>{{Archive|URL=2022.02.11-103224/https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=1772}}</ref>
For those with this variation who are [[CTF]] are typically born with vaginal aplasia, an [[Clitoromegaly|enlarged clitoris]], and may have only a single vaginal hole that connects both urinal output and sexual output. Both CTM and CTF individuals with this variaton tend to have [[Ambiguous Genitalia|ambiguous genitals]] as well.
Both CTM and CTF individuals with this variation tend to have [[Ambiguous Genitalia|ambiguous genitals]] as well. Infertility is common with this variation.<ref>{{Archive|Site=web|URL=20231022020758/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926925/}}</ref>
They can have any internal sex organs, though asymmetrical gonads and other structures are common.<ref>https://www.cincinnatichildrens.org/health/m/mixed-gonadal-dysgenesis</ref> Depending on how the gonads develop, the output of estrogen and testosterone may vary, however it is common that those with this variation tend to have a [[masculine]] puberty, making CTF individuals with this variation possibly also have [[hyperandrogenism]]. ▼
▲TheyOne with this variation can have any internal sex organs, though asymmetrical gonads and other structures are common.<ref> {{Archive|URL=2022.02.11-103457/https://www.cincinnatichildrens.org/health/m/mixed-gonadal-dysgenesis }}</ref> Depending on how the gonads develop, the output of estrogen and testosterone may vary ,; however , it is common thatfor those with this variation tend to have a [[masculine]] puberty, making CTF individuals with this variation possibly also have [[hyperandrogenism]].
It is important to note that not all the symptoms listed above are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation.
== History ==
The earliest mention of Mixed Gonadal Dysgenesis appears to have been in 1992, with Richard E. Behrman in the 14th edition of the Nelson textbook of Pediatrics.<ref>{{Archive|URL=2012.05.30-123442/http://www-personal.umd.umich.edu/~jcthomas/JCTHOMAS/1997%20Case%20Studies/N.Justus.html}}</ref>
== Flag ==
TheMod flag was coined byHermy afrom Tumblr userblog referred[https://web.archive.org/web/20231022012137/https://www.tumblr.com/pride-color-schemes topride-color-schemes] ascoined 'Modthe Hermy'flag on or before June 15th of, 2017, and was posted by Tumblr user pride-color-schemesit. It has no confirmed meaning.<ref name=":0" />
== Resources References==
[[Category:Intersex Traits]]
[[Category:Verified Resources]]
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