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[[File:Davpdjz-b7bb45df-a6c5-4a87-ace5-caa4ada3db71.png|thumb|220x220px|The 45,X/46,XY mosaicism
'''45,X/46,XY Mosaicism''' or '''Mixed Gonadal Dysgenesis''' is a rare [[intersex]] variation affecting 1 in 15,000 individuals. It is a chromosomal karyotype where some of one's cells have an X chromosome, and some have XY chromosomes.<ref name=":0">{{Archive|URL=2022.02.11-103018/https://pride-color-schemes.tumblr.com/post/161844110960/45x46xy-mosaicism}}</ref> Each case differs depending on the exact location and amount of X and XY cells in one's body.
▲[[File:Davpdjz-b7bb45df-a6c5-4a87-ace5-caa4ada3db71.png|thumb|220x220px|The 45,X/46,XY mosaicism pride flag.]]
Those with this variation who are [[CTM]] are typically shorter than usual, with a [[AMAB Hypogonadism|low output of testosterone]], and typically have a [[Agenital|micropenis]] (though they may have a common penis as well).<ref>{{Archive|URL=2022.02.11-103224/https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=1772}}</ref>
== History ==▼
The earliest mention of Mixed Gonadal Dysgenesis appears to have been in 1992, with Richard E. Berhrman in the 14th edition of the Nelson textbook of Pediatrics.▼
For those with this variation who are [[CTF]] are typically born with vaginal aplasia, an [[Clitoromegaly|enlarged clitoris]], and may have only a single vaginal hole that connects both urinal output and sexual output.
== Flag ==▼
Both CTM and CTF individuals with this variation tend to have [[Ambiguous Genitalia|ambiguous genitals]] as well. Infertility is common with this variation.<ref>{{Archive|Site=web|URL=20231022020758/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926925/}}</ref>
One with this variation can have any internal sex organs, though asymmetrical gonads and other structures are common.<ref>{{Archive|URL=2022.02.11-103457/https://www.cincinnatichildrens.org/health/m/mixed-gonadal-dysgenesis}}</ref> Depending on how the gonads develop, the output of estrogen and testosterone may vary; however, it is common for those with this variation to have a [[masculine]] puberty, making CTF individuals with this variation possibly have [[hyperandrogenism]].
▲The earliest mention of Mixed Gonadal Dysgenesis appears to have been in 1992, with Richard E.
Mod Hermy from Tumblr blog [https://web.archive.org/web/20231022012137/https://www.tumblr.com/pride-color-schemes pride-color-schemes] coined the flag on or before June 15th, 2017, and posted it. It has no confirmed meaning.<ref name=":0" />
==References==
[[Category:Intersex Traits]]
[[Category:Verified Resources]]
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